The largest prospective cohort study evaluated the impact of coffee consumption on all-cause mortality and involved 229,000 men and 173,000 women, who were followed for up to 13 years.
After adjustment for smoking status and other potential confounders, associations between coffee consumption (either caffeinated or decaffeinated) and reduced all-cause mortality were evident at relatively low levels of consumption (2 to 3 cups/day).
Compared to non–coffee drinkers, the risk of all-cause mortality among men and women who consumed 2 to 3 cups of coffee daily was 0.90 and 0.87.
The apparent benefit of coffee was similar for individuals with high levels of coffee consumption, including those who drank six or more cups of coffee per day. [UpToDate]
(Ref: Freedman ND, Park Y, Abnet CC, et al. Association of coffee drinking with total and cause-specific mortality. N Engl J Med 2012; 366:1891).
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