Vitamin D deficiency is associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2.
In a study of Saudi T2 diabetes patients receiving oral vitamin D3 (2000 IU/day), supplementation of vitamin D at 18 months significantly improved lipid profile with a favorable change in HDL/LDL ratio, and HOMA-β function, which were more pronounced in T2DM females.
The present interventional study performed in an Arab population suggests that daily 2000 IU vitamin D3 supplementation in a vitamin D deficient T2DM population is associated with measurable cardioprotective indices.
Supplementation to achieve higher levels of vitamin D remains a promising adjuvant therapy for T2DM patients.
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