Patients undergoing percutaneous coronary intervention
(PCI), who had well-controlled LDL cholesterol (LDL-C) but persistently high
levels of high-sensitivity C-reactive protein (hsCRP) were at a more than
twofold greater risk for major adverse cardiac and cerebrovascular events,
compared with those who had low LDL-C and low hsCRP levels.
Over a 1-year follow-up there was a stepwise increase in
major adverse cardiovascular and cerebrovascular events.
Patients were categorized according to their serial hsCRP
levels, with high hsCRP defined as at least 2 mg/L.
A stepwise increase in the primary end point of major
adverse cardiac and cerebrovascular accident (MACCE), defined as death,
myocardial infarction, or stroke, within 1 year of the second hsCRP measurement
was noted.
The study, published in the May 21 issue of the Journal
of the American College of Cardiology, was a retrospective analysis of a
prospective PCI registry from Mount Sinai Hospital.
(Medscape excerpts)
Comments
·
High LDL levels with no
underlying inflammation may have no consequence.
·
Normal LDL with high
inflammation may be abnormal.
·
Always do lipid profile with
hsCRP.
Dr KK Aggarwal
Padma Shri
Awardee
President Elect Confederation of
Medical Associations in Asia and Oceania
(CMAAO)
Group
Editor-in-Chief IJCP Publications
President Heart
Care Foundation of India
Past National President
IMA
