Showing posts with label benzodiazepines. Show all posts
Showing posts with label benzodiazepines. Show all posts

Thursday, April 18, 2019

Can benzodiazepines, opioids and muscle relaxants be combined in one patient?


The answer is No. This can be deadly. Never prescribe all three drugs to one patient. If a patient overdoses on opioids, the doctor who prescribed them can expect a review of records. Prescribing two of the three drugs is even more risky.

If the combination is truly medically necessary, then your rationale for prescribing them should be documented.

Never prescribe even one of these medications without performing and documenting a thorough assessment and diagnosing a condition that necessitates their prescription.

Always bear in mind that the patient may already be receiving an opioid from one provider or a benzodiazepine from another provider and/or a muscle relaxant from a third provider.

So, before prescribing any of these medications, tick off these questions from your checklist:

1.     Does my patient have a medical diagnosis that calls for this medication?
2.     Could the benefit be achieved with nonsteroidal drug, or through physical therapy or other nonpharmacologic treatment?
3.     Is there a risk of abuse in my patient?
4.     Have I done a urine drug screen?
5.     Do I have a written agreement with this patient about the goals of care and the conditions under which I will prescribe this medication?
6.     Am I prepared to follow-up and assess whether the medication is effective? Will I stop prescribing the medication and taper it off if the patient is not improving?
7.     Am I following opioid prescribing guidelines, and am I following them? 


Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA

Sunday, December 23, 2018

Naloxone should be coprescribed with opioids for all patients at risk for overdose



New guidelines from the US Department of Health and Human Services (HHS) recommend that naloxone should be prescribed or coprescribed with opioids to individuals at high risk of an overdose, including, but not limited to: individuals who are on relatively high doses of opioids, take other medications which enhance opioid complications, or have underlying health conditions.

The guideline also recommends that doctors should also educate patients and those who are likely to respond to an overdose, including family members and friends, on when and how to use naloxone.

The following patients should be prescribed or coprescribed naloxone:

·         Are receiving opioids at a dosage of 50 morphine milligram equivalents (MME) per day or greater
·         Have respiratory conditions such as chronic obstructive pulmonary disease (COPD) or obstructive sleep apnea (regardless of opioid dose)
·         Have been prescribed benzodiazepines (regardless of opioid dose).
·         Have a non-opioid substance use disorder, report excessive alcohol use, or have a mental health disorder (regardless of opioid dose)

Patients at high risk for experiencing or responding to an opioid overdose have also been defined. These include individuals:

·         Using heroin, illicit synthetic opioids or misusing prescription opioids
·         Using other illicit drugs such as stimulants, including methamphetamine and cocaine, which could potentially be contaminated with illicit synthetic opioids like fentanyl
·         Receiving treatment for opioid use disorder, including medication-assisted treatment with methadone, buprenorphine, or naltrexone
·         With a history of opioid misuse that were recently released from incarceration or other controlled settings where tolerance to opioids has been lost


Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Immediate Past National President IMA