Showing posts with label cardiovascular disease. Show all posts
Showing posts with label cardiovascular disease. Show all posts

Sunday, May 5, 2019

The four keys to prevent cardiovascular disease


An estimated 80% of all CVD cases — heart disease, heart attack, heart failure, and stroke — can be prevented. The key is to control high blood pressure and high cholesterol and to maintain healthy habits, such as exercising regularly, eating a plant-based diet, getting enough sleep, and not smoking.

Exercise: Guidelines recommend 30 minutes of moderate-intensity exercise five times a week. "Doing more is better.

·         Walk for 5 minutes every 2 hours. Do a set or two of push-ups either on the floor or against the kitchen counter.
·         Perform up to 10 repetitions of stand-and-sit exercises, where you rise from a chair not using your arms and then sit down again.
·         Find opportunities to do extra movements. For example, park farther away from the grocery store, take the stairs, and do simple yard work like weeding, planting, and raking. Every bit of everyday movement can count toward your overall exercise requirements.

Diet: Focus on plant foods; minimize intake of red meat, especially processed meat.

Sleep: Guidelines from the American Academy of Sleep Medicine and the Sleep Research Society recommend adults get at least 7 hours of sleep per night on a regular basis. Studies have found that getting less than this amount is associated with heart disease risk factors like higher stress, increased inflammation, high blood pressure, and weight gain. Sleep apnea can also increase the risk. According to a study published online Feb. 12, 2018 in the Journal of Sleep Disorders & Therapy, people with sleep apnea are more likely to also have heart failure, an irregular heartbeat and diabetes

Numbers: Keep the lower BP, LDL cholesterol, abdominal circumference and fasting sugar < 80

(Source: Harvard Health Watch)

Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA

Saturday, April 6, 2019

The top 10 causes of death in India



India continues to face a twin burden of diseases, both communicable and non-communicable diseases (NCDs) as is evident from the list of top 10 causes of death in the country. Cardiovascular diseases (CVDs) are the leading cause of death in India as they are globally. Diarrheal diseases come next.

As per data, the top 10 causes of death in India are:

1.     Cardiovascular diseases
2.     Diarrheal diseases
3.     Neonatal disorders
4.     Non-communicable diseases
5.     Chronic respiratory diseases
6.     Diabetes
7.     Mental disorders
8.     Unintentional injuries
9.     Neoplasms
10.  Nutritional deficiencies

(Source: World Bank India, Population Reference Bureau (2017) India)

The major risk factors for CVDs include high BP, abnormal blood cholesterol, tobacco and alcohol use, diabetes, obesity, unhealthy diet, sedentary life, psychosocial stress.

The factors responsible for the rising prevalence of type 2 diabetes are again unhealthy diet, lack of physical activity, harmful use of alcohol, over-weight/obesity, tobacco use etc.

Common mental disorders such as depression, anxiety often coexist with other NCDs and they share many risk factors. They occur not only as an outcome of NCDs, but mental disorders are also associated with behaviors (alcohol use, tobacco smoking, unhealthy diet, reduced physical activity), which increase the risk of other NCDs.

Unintentional injuries are an important cause of death in India. Road traffic injuries, falls and drowning constitute the three leading causes of deaths due to unintentional injury. Diabetes is an important cause of falls in the elderly.

The traditional risk factor for chronic respiratory disease such as COPD, asthma has been tobacco smoking. But, now, non-smoking risk factors such as air pollution, occupational chemicals and dusts are emerging as important contributors to chronic respiratory diseases in developing countries like India.

Air pollution has now emerged as a major environmental risk factor for health. It is a major potentially modifiable risk factor for chronic diseases as well as acute disease events such as stroke, acute heart attack and acute bronchial asthma.

When we talk of communicable diseases, the major risk factors for diarrheal diseases, the second largest cause of deaths in the country include poor sanitation and lack of hygiene. Around 1.1 million children die each year in India, including approximately 1.1 lakh deaths due to diarrhea. Although other factors such as low socioeconomic status, poor maternal literacy, low birth weight, inadequate breastfeeding, malnutrition also contribute the disease burden.

Enlisting the risk factors shows that poor sanitation and lack of hygiene are the major risk factors for communicable diseases. While, most NCDs such as heart disease, diabetes, cancer, respiratory diseases share common behavioral risk factors (lack of physical activity, unhealthy diet, tobacco use, excessive intake of alcohol) and metabolic risk factors (obesity, hypertension, dyslipidemia, diabetes).

The INTERHEART study published in the September 3, 2004 issue of the Lancet identified nine traditional risk factors for an acute heart attack: Abnormal lipids, smoking, hypertension, diabetes, abdominal obesity, psychosocial factors, consumption of fruits, vegetables, and alcohol, and regular physical activity. As per the study, more than 90% of the global risk for acute MI is predicted by these nine traditional risk factors.

Hence, preventive strategies for NCDs must focus on these overlapping risk factors. Diarrheal diseases can be tackled via safe drinking water and improving hygiene and sanitation.

Much of the disease burden in the country can be prevented by behavioral changes and adopting a healthy lifestyle and practicing good hygiene.

Swachh Bharat mission, which promotes hygiene and sanitation and also aims to make India completely Open Defecation-free (ODF) by October 2019, is a step to reduce the burden of diarrheal diseases in the country. A WHO report in 2018 estimated that at least 1.8 lakh diarrheal deaths have been averted in rural areas since the launch of Swachhta Bharat Mission (TOI).

India has a National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS). In the interim budget, the budgetary allocation for NPCDCS, national mental health program, tobacco control program were reduced.

India will soon elect a new government.

It remains to be seen if the next government will have the political will to tackle the epidemic of NCDs in the country and according increase the budgetary allocation when they present the full budget.


Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA

Wednesday, March 27, 2019

Screening test for endothelial function

Brachial artery ultrasound is a commonly used and widely accepted method to evaluate the peripheral macrovascular endothelial function.

Inflating the blood pressure cuff at suprasystolic pressures for 5 minutes occludes the upper arm proximal to the ultrasound measurement. When this occlusion is released, endothelial-dependent, nitric oxide NO-driven, flow-mediated dilation (FMD) of the brachial artery occurs due to an increase in shear stress. Both diameter and blood velocity are measured before and after occlusion at the end of the diastole. The results are reported as a percent change from baseline.

The reported vascular response to increased flow has been shown to be a surrogate for measuring coronary endothelial function.

The stimuli for measuring endothelial reactivity include reactive hyperaemia, exercise, mental stress, or sympathetic nervous activation through the cold pressor test.

Peripheral endothelial dysfunction, as measured by FMD of the brachial artery, was shown to be associated with a higher rate of incident adverse cardiovascular disease (CVD) events during a five-year follow-up period in the MESA study.

For the screening test, an ultrasound is not needed. Just inflate the blood pressure cuff at suprasystolic pressures for five minutes and occlude the upper arm. When the occlusion is released, there is an endothelial-dependent, nitric oxide NO-driven, flow-mediated dilation and increased velocity of the brachial artery. Clinically, this presents as a sudden feeling of warmth in the arm, which suggests normal endothelial function.


Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA

Tuesday, November 27, 2018

Person Centric Medicine: Aspirin for primary prevention of cardiovascular disease and cancer




People Centric Approach in secondary prevention of cardiovascular disease: the absolute benefits of aspirin on occlusive events are greater than the absolute harm of major bleeding. All must get it.
Personal Centric Approach in primary prevention: the decision whether to use aspirin for primary prevention of cardiovascular disease and cancer be made based on shared decision-making, taking into account the probable benefits and harms of aspirin relative to the specific patient.

Three recent large randomized trials evaluating all-cause mortality associated with aspirin use indicate that the benefits and harms of aspirin for primary prevention are very closely balanced [1-5].

In both the ASCEND trial in patients with diabetes as well as the ARRIVE trial in patients with moderate CVD risk, the risk of all-cause death was similar with or without aspirin [1,5].

In the ASPREE trial of individuals 70 years or older, the risk of death was higher with aspirin (13 versus 11 percent) [2-4].

References

1.      ASCEND Study Collaborative Group, Bowman L, Mafhac approachm M, et al. Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. N Engl J Med 2018; 379:1529.
2.      McNeil JJ, Woods RL, Nelson MR, et al. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. N Engl J Med 2018; 379:1499.
3.      McNeil JJ, Wolfe R, Woods RL, et al. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. N Engl J Med 2018; 379:1509.
4.      McNeil JJ, Nelson MR, Woods RL, et al. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med 2018; 379:1519.
5.      Gaziano JM, Brotons C, Coppolecchia R, et al. Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial. Lancet 2018; 392:1036.

Dr KK Aggarwal
Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Immediate Past National President IMA







Saturday, January 12, 2013

Tweet of the day @drkkaggarwal


1. One can book direct flights to any domestic destination on spice Jet @ 2013 for travel between 1st February and 30th April 2013.
2. Erectile dysfunction has 44% increased risk of cardiovascular disease & 25% increased risk of death. [January, Circulation]
3. Erectile dysfunction is associated with a significant 62% increased risk of heart attack and a 39% increased risk of paralysis. [January, Circulation]
4. Consuming fructose appears to cause changes in the brain that may lead to overeating, a new study suggests in Jan issue of JAMA.
5. The new ADA guidelines raise the target for systolic upper blood pressure from <130 mm Hg to <140 mm Hg in diabetics.
6. FDA has issued another safety communication about QTc prolongation and potentially fatal cardiac arrhythmias in patients treated with ondansetron . 
7. Prolongation of the QT interval and torsades de pointes is associated with macrolide antibiotics, such as erythromycin, clarithromycin nd Azithromycin
8. Revisiting 2012: major change in the previously-issued HIV treatment guidelines; antiretroviral therapy is now recommended in all HIV-infected patients, regardless of CD4 cell counts.
9. Revisiting 2012: Start ARV in every HIV patient as more potent agents with less toxicity are available
10. Revisiting 2012: Start ARV in every HIV patient as untreated HIV is associated with increased morbidity & mortality due to heart, kidney & liver disease & malignancy
11. Aspirin plus clopidogrel is no better than aspirin alone for preventing recurrent stroke.