Those at risk of heart attack or other cardiovascular events taking a low dose aspirin holiday can increase their risk of acute heart attack as per a large case-controlled study of 39513 patients aged 50-84 by Dr Luis Garcia Rodriguez, of the Spanish Centre for Pharmacoepidemiologic Research in Madrid and published in British Medical journal.
Compared with those taking aspirin, individuals prescribed aspirin for secondary prevention who had recently discontinued the drug had a significantly increased risk of nonfatal heart attacks or death from coronary heart disease combined and nonfatal heart attacks
Aspirin holiday can cause four more cases of nonfatal heart attacks for every 1,000 patients over a period of one year.
The current American Heart Association/American College of Cardiology practice guidelines recommend 75 mg to 162 mg of aspirin as low dose aspirin per day.
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