Dr KK Answers: Should I double the dose of clopidogrel if there is resistance?

The risk of stent clot (thrombosis) is significantly increased in patients who demonstrate resistance to the drug clopidogrel.

GRAVITAS trial compared a high to a standard dose of clopidogrel in over 2000 such patients and showed no difference in the incidence of major cardiovascular events at six months.

Source: JAMA 2011; 305:1097