1. Profuse watery diarrhea with signs of hypovolemia
2. Passage of many small volume stools containing blood and mucus
3. Bloody diarrhea
4. Temperature ≥38.5ºC (101.3ºF)
5. Passage of ≥6 unformed stools per 24 hours or a duration of illness >48 hours
6. Severe abdominal pain
7. Hospitalized patients or recent use of antibiotics
8. Diarrhea in the elderly (≥70 years of age) or the immunocompromised
9. Systemic illness with diarrhea, especially in pregnant women (in which case listeriosis should be suspected)
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