There is a strong negative clopidogrel/esomeprazole interaction, compensated by increasing the dose of clopidogrel to 150mg or replacing esomeprazole with ranitidine. That is a simple solution to the PPI-induced clopidogrel resistance. [Moceri P, Doyen D, Cerboni P, Ferrari E; Thrombosis Research (Jul 2011)]
Dr K K Aggarwal is Padmashri and Dr B C Roy National Awardee, President Heart Care Foundation of India, Dean Board of Medical Education Moolchand Medcity, Sr. Physician & Cardiologist, Visiting professor Clinical Research DIPSAR, Past President Delhi Medical Association, Past Academic and Research Wing Head IMA, Chairman Ethics Committee Delhi Medical Council.
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