Triphala (TRP), a herbal extract, has been shown to affect lymphocytes and natural killer T (NKT) cell function. It has been shown to ameliorate bronchial hyperreactivity through immune-cell modulations.
In a study carried out at the Division of Allergy, Immunology and Pulmonary Medicine,Washington University in Saint Louis,Saint Louis,MO, asthma mouse models were generated through intraperitoneal (IP) injections of ovalbumin (OVA)/2 weeks followed by repeated intranasal OVA challenges.
Mice were then treated with normal saline (OVA/NS) or Triphala (OVA/TRP). Data were compared with mice treated with inhaled budesonide.
Both TRP and budesonide significantly ameliorated functional and histological OVA-induced bronchial hyperreactivity.
Triphala causes a significant decrease in bronchial reactivity. It alters immune-cell distributions and show anti-oxidative properties. Immune-cell modulation with triphala can ameliorate lung injury.
(Ref: Horani A, Shoseyov D, Ginsburg I, et al. Triphala (PADMA) extract alleviates bronchial hyperreactivity in a mouse model through liver and spleen immune modulation and increased anti-oxidative effects. Ther Adv Respir Dis 2012 Aug;6(4):199-210).
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