(Medscape Excerpts)
Patients who regularly take glucosamine supplements may
have a moderately lower risk for cardiovascular disease (CVD) events, results
from 22 centers participating in the UK Biobank suggest.
Glucosamine use was associated with a 15% lower risk for
total CVD events and a 9% to 22% lower risk for stroke, coronary heart disease
and CVD death after adjustment for age, sex, body mass index, race, lifestyle
factors, diet, medications, and other supplements.
A few other cohort studies have raised this question
including the Vitamins and Lifestyle (VITAL) cohort study, in which high
glucosamine use (at least 4 days per week for at least 3 years) was associated
with a 17% lower adjusted total mortality risk.
Animal studies suggest the associations may be driven by
the anti-inflammatory properties of glucosamine or that the popular supplement
may mimic a low carbohydrate diet by decreasing glycolysis and increasing amino
acid catabolism, the authors write in their article published online May 14 in
BMJ.
Dr KK Aggarwal
Padma Shri
Awardee
President Elect Confederation of
Medical Associations in Asia and Oceania
(CMAAO)
Group
Editor-in-Chief IJCP Publications
President Heart
Care Foundation of India
Past National President
IMA
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